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How to optimize your microdose with Immuno Defense +
Before Microdosing with Psilocybin it's important to take care of your gut in what is called the Pre-Cycle. This may give you a more positive and beneficial experience. The Gut, also known as the 'second brain' has it's own nervous system and has a direct impact on your mental and physical health. 1. AbsorptionThe gut microbiome may influence the absorption and metabolism of psilocybin in the gut, which could impact its pharmacokinetics and pharmacodynamics. 2. Serotonin Psilocybin is metabolized into psilocin, which is a serotonin receptor agonist and has psychoactive effects. The gut microbiome may play a major role in the production and metabolism of serotonin, which could impact the effects of psilocybin. 3. Microbiome-brain axisThe gut microbiome is known to communicate with the brain through the microbiome-gut-brain axis, and there is evidence that the gut microbiome can impact the brain's response to stress, anxiety, and depression. Some studies suggest that psilocybin may also interact with the gut microbiome to influence the brain and modulate mood and mental states.f February 2023 How can you maintain a healthy gut microbiome to maximize the benefits of microdosing with psilocybin? The answer lies in supplementing your diet with 'Immuno Defense +,' a unique blend of four powerful medicinal mushrooms – Lion's Mane, Reishi, Chaga and Turkey Tail. THE 5 KEY BENEFITS of Immuno Defense+ Supports gut healthThe medicinal mushrooms in Immuno Defense + contain beta-glucans, which are known to support gut health by promoting the growth of beneficial bacteria in the gut.Promotes a healthy immune systemThe mushrooms in Immuno Defense + contain antioxidants and anti-inflammatory compounds that help support a healthy immune system.Balances gut bacteriaThe blend of mushrooms in Immuno Defense + helps to balance the gut bacteria and maintain a healthy gut microbiome.Supports mental healthThe medicinal mushrooms in Immuno Defense + contain compounds that have been shown to support mental health and reduce stress and anxiety.Improves digestionThe mushrooms in Immuno Defense + have been shown to improve digestion and reduce bloating and constipation.In conclusion, if you're interested in microdosing with psilocybin, it's important to prioritize your gut health. 30% DISCOUNT Discount code: GUT30Discount is valid until Wednesday 8th of February 2023 Optimize your Cycle Supplementing your diet with Immuno Defense + can help you achieve a healthy gut microbiome, which can in turn maximize the benefits of microdosing with psilocybin. With its unique blend of four powerful medicinal mushrooms, Immuno Defense + is the perfect supplement for those who want to take their microdose experience to the next level.
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4 healing Benefits of Vitamin C and Microdosing
Vitamin C is used in combination with your Microdosing cycle to enhance the therapeutic effects of psilocybin. We explain the benefits: 1. BioavailabilityVitamin C Increases the bioavailability of psilocybin, by increasing the activity of the liver enzyme CYP450, which is involved in the metabolism of psilocybin (1) (2). This increases the amount of level of psilocybin that reaches the brain which leads to longer lasting and stronger experience2. Cell ProtectionVitamin C acts as an antioxidant that can help protect cells from damage caused by harmful molecules called free radicals. Vitamin C helps to improve the healing and regeneration of cells. (3) Also Vitamin C supports the Immune system by enhancing the activity of white blood cells to fight off infections and protect against stressors which contribute to cell protection.3. Reduce inflammationThere have been several studies that suggest supplementing with vitamin C improved symptoms of depression in individuals who were deficient in the nutrient (4). Vitamin C may help regulate levels of neurotransmitters such as serotonin and dopamine, which play a role in mood regulation. Also it has anti-inflammatory effects which may also be beneficial for individuals with depression, as chronic low-grade inflammation has been linked to the development of mood disorders. (5)4. Reduce side effectsVitamin C may help to protect the brain from some of the negative effects of psilocybin such as nausea, anxiety or paranoia by reducing oxidative stress in the brain. Reducing oxidative stress in the brain may have several benefits including improving brain function, reducing risk of neurodegenerative diseases and supporting overall brain health. (6) 1. "Metabolic fate of psilocybin in the rat," Journal of Pharmacy and Pharmacology, 19912. "In vitro evaluation of the effect of ascorbic acid on cytochrome P450 enzymes," Psychopharmacology, 20023. "Vitamin C: antioxidant and immunomodulator," Nutrition Reviews, 2002.4. "The effect of vitamin C supplementation on symptoms of depression in patients with major depressive disorder: a randomized controlled trial," Journal of Affective Disorders, 2016.5. Vitamin C supplementation reduces inflammation and oxidative stress in patients with major depressive disorder," Nutritional Neuroscience, 2018.6. "Vitamin C modulates oxidative stress, neuroinflammation and neurodegeneration," Banerjee P et al., Journal of Neurochemistry, 2015.
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The Fatigue Fighting Fungi: the Power of Turkey Tail
Tired of being Tired? Turkey Tail may be your answer! At Earth Resonance we believe in the power of natural remedies, that is why we offer a range of wild harvested medicinal mushrooms to support your well being. We are highly selective in what we add to our product line. Besides our famous Natural Psilocybe we have 5 other Natural Supplements we have developed and we source and produce for you with care. Let's talk about the fatigue fighting benefits of Turkey Tail. History of useTurkey tail mushroom, also known as Coriolus versicolor or Trametes versicolor, is a type of medicinal mushroom that has been used in Chinese and Japanese Medicine for centuries to boost immunity and and improve overall health. It is now widely recognized for its medicinal properties and is often considered the #1 anti-fatigue mushroom. Earth's Resonance Turkey Tail grows in the wild forests of Mongolia and is sustainably harvested, produced and packaged.` THE #1 ANTI-FATIGUE MUSHROOM5 key reasons how Turkey Tail helps you fight fatigue Chronic fatigue syndrome (CFS) is a condition characterized by persistent fatigue that is not explained by any underlying medical condition. The exact cause of CFS is not known, but it is thought to be related to a dysfunction of the immune system. If you're looking for a natural way to reduce fatigue, Turkey tail mushroom may be the answer. 1. Improved energy metabolismTurkey tail has been found to have compounds that support energy metabolism. Studies have shown that Turkey tail can help to improve the mitochondria function, which is responsible for producing energy in the cells. This can help to reduce fatigue and improve overall energy levels. 2. Immune System SupportTurkey tail mushroom is rich in compounds such as beta-glucans, polysaccharides and proteoglycans which have been found to stimulate the production of white blood cells and help to boost the immune system. 3. Anti-inflammatory propertiesTurkey tail has antioxidant properties that can help to neutralize free radicals and reduce inflammation in the body. Inflammation is thought to play a role in the development of CFS, and reducing inflammation can help to reduce the symptoms of CFS. 4. Stress response improvementTurkey tail is also rich in beta-glucans, which can help to improve the body's response to stress. By improving the body's response to stress, turkey tail may help to reduce the symptoms of CFS, such as fatigue and weakness. 5. Protect mitochondria Ergothioneine is an antioxidant that is found in high concentrations in Turkey tail, and it has been found to protect the mitochondria from damage. It acts as a scavenger of free radicals, which can cause damage to the mitochondria, and it has been found to have a protective effect on the mitochondria by preventing the formation of reactive oxygen species (ROS). Ergothioneine also helps to maintain the integrity of the mitochondrial membrane and can improve the function of the mitochondria, leading to better energy production and reducing fatigue. How to use? Add Turkey Tail to your daily routine. It's not only energizing but also tastes delicious. Brew your own Turkey Tail Tea. Steep it in warm water to unlock all the bioactive compounds and enjoy the benefits of this powerful Mushroom. Do not use boiling water, 80 degrees Celsius is best. You can combine Turkey Tail safely with Natural Psilocybe. 30% DISCOUNT Discount code: FEELALIVE30Discount is valid until Wednesday 1th of February 2023 ORDER TURKEY TAIL NOW
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Discover 5 major reasons why Chaga is the #1 ANTI-AGING MUSHROOM
At Earth Resonance we believe in the power of natural remedies. That is why we offer a range of wild harvested medicinal mushrooms to support your wellbeing. Add Chaga to your daily routine and brew a delicious tea to protect your youth and vitality. History of useChaga Mushroom, also known as Inonotus Obliquus, is a type of fungus that grows on the bark of birch trees. It has a long history of use in traditional medicine in various cultures where it has been used for centuries to treat digestive disorders, cancer and infections. As we age, our bodies naturally begin to deteriorate and we become more susceptible to diseases and illnesses. However, Chaga has been the subject of several research studies conducted in medical institutions and universities around the world. Different bioactive compounds found such as Betulinic Acid have shown to increase lifespan, slow down the aging process and even reduce tumor growth. Discover 5 reasons why Chaga is the #1 ANTI-AGING MUSHROOM: Antioxidant properties: Chaga contains high levels of antioxidants, including melanin, superoxide dismutase (SOD), and polysaccharides. These antioxidants help to neutralize free radicals, which are unstable molecules that can damage cells and contribute to aging. By neutralizing free radicals, antioxidants can help to protect cells from damage, reduce inflammation and improve overall health, which may help to slow down the aging process. Anti-inflammatory properties: Chaga also contains compounds that have anti-inflammatory properties, such as beta-glucans. Inflammation is a natural response to injury or infection, but chronic inflammation caused by unhealthy diet, smoking or alcohol can contribute to aging and the development of chronic diseases. By reducing inflammation, Chaga may help to protect against the negative effects of aging and improve overall health. Immune system support: Chaga has been found to boost the immune system, making it more effective in fighting off infections and illnesses, which can contribute to aging. The beta-glucans present in Chaga have been found to stimulate the production of white blood cells, which help to fight off infections, and also act as a natural defense against cancer cells. DNA protection: Chaga has been found to have protective effects on DNA, which can help to reduce the risk of mutations and cancer, and may help to slow down the aging process. Melanin, a pigment found in Chaga, has been found to protect the DNA from damage caused by free radicals, and may help to repair damage that has already occurred. Anti-cancer properties: Chaga has been found to have anti-cancer properties, and has been shown to inhibit the growth of cancer cells. The beta-glucans present in Chaga have been found to inhibit the growth of cancer cells, and also act as a natural defense against cancer cells. This can help to reduce the risk of developing cancer. Betulinic acid can inhibit the formation of tumors and angiogenesis (the formation of new blood vessels in tumors) which can further slow down the growth of cancer cells. At Earth Resonance we are highly selective in what we add to our product line. Besides our famous Natural Psilocybe we have 5 other Natural supplements we have developed, source and produce for you with care. Add Chaga to your daily routine. It's not only healthy but also tastes delicious. Brew your own Chaga Tea. Steep it in warm water (80 degrees Celsius, not boiling water) to unlock all the bioactive compounds and enjoy the benefits of this powerful Mushroom. Order now!
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Exploring the Therapeutic Benefits of Psilocybin for Women
Psilocybin, a naturally-occurring psychedelic compound found in certain types of mushrooms, has been gaining attention in recent years for its potential therapeutic benefits, particularly for women. The compound is known to produce profound changes in the way people think and perceive the world, and research has shown that it may have a wide range of therapeutic benefits for women. In this article, we will take an in-depth look at the key benefits of psilocybin for women, as well as provide information on how to consume it safely. 1. Treatment of menstrual related disorders: Psilocybin has shown promise in the treatment of menstrual related disorders such as premenstrual dysphoric disorder (PMDD) and endometriosis. These disorders can be debilitating and often have a significant impact on a woman's quality of life. Psilocybin therapy has been found to produce rapid and long-lasting improvements in symptoms of these disorders, with many women reporting a decrease in pain and emotional symptoms. The exact mechanisms by which psilocybin can help to alleviate the symptoms of menstrual related disorders are not yet fully understood. However, research suggests that psilocybin may work by influencing the activity of certain neurotransmitters in the brain, such as serotonin, which plays a role in regulating mood and emotions. Additionally, psilocybin has been found to have anti-inflammatory properties, which may help to alleviate the pain and discomfort associated with menstrual cramps. 2. Addressing Trauma: Psilocybin has also been found to be effective in addressing trauma, particularly for women who have experienced sexual abuse or assault. Many women report feeling a greater sense of control and agency over their own healing process when using psilocybin, and some have reported that it has helped them to process and integrate traumatic experiences. Psilocybin may help to address trauma by influencing the activity of neurotransmitters in the brain such as serotonin and dopamine, which play a role in regulating mood and emotions. Additionally, psilocybin has been found to have a positive effect on cognitive flexibility and the ability to think abstractly, which may help individuals to gain a different perspective on their traumatic experiences. 3. Improving self-esteem and body image: Psilocybin has been found to have a positive effect on self-esteem and body image for women. Research has shown that psilocybin can help to reduce feelings of self-consciousness, shame, and insecurity, and can improve feelings of self-acceptance and self-love. Psilocybin may help to improve self-esteem and body image by influencing the activity of neurotransmitters in the brain such as serotonin, which plays a role in regulating mood and emotions. Additionally, psilocybin has been found to have a positive effect on cognitive flexibility and the ability to think abstractly, which may help individuals to gain a different perspective on their self-image and self-worth.4. Relief from menstrual cramps: Microdosing psilocybin has been found to have a positive effect on reducing menstrual cramps and other physical symptoms associated with menstruation. Psilocybin has been found to have anti-inflammatory properties, which may help to alleviate the pain and discomfort of menstrual cramps. Microdosing, which involves taking small doses of psilocybin, is a safe and effective way to take advantage of these benefits without experiencing the more intense psychedelic effects of larger doses. 5. Improving overall mood: Microdosing psilocybin has been found to have a positive effect on overall mood, particularly for women. Psilocybin has been found to have an impact on the levels of serotonin, a neurotransmitter that plays a role in regulating mood. Microdosing psilocybin can help to improve mood, reduce anxiety, and promote a sense of well-being. It's important to note that while psilocybin has shown promise in the treatment of these conditions, it's still in early stages of research and should not be used as a replacement for traditional medical treatment. It's also important to consume psilocybin in a controlled setting, with the guidance of a medical professional or a therapist trained in psychedelic therapy, to ensure safety and optimal benefit. In conclusion, psilocybin has been found to have a wide range of therapeutic benefits for women, particularly in the treatment of menstrual related disorders, addressing trauma, improving self-esteem and body image, relieving menstrual cramps, and improving overall mood. However, it's important to approach psilocybin therapy with caution and under the guidance of a medical professional or a therapist trained in psychedelic therapy to ensure safety and optimal benefit."
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Why caffeine is not supporting your wellbeing
Why Caffeine is not supporting your wellbeing You know that friend who can’t drink coffee without feeling shaky or anxious? Do you find that when you drink caffeine past noon you can’t sleep that night? Perhaps after you have a cup or two you find yourself extremely awake and energized but feeling restless and distracted? Despite the commonly known limitations and negative effects of caffeine, it is still an extremely touted substance. Many people look over the downfalls of caffeine simply because they enjoy the initial feeling of it, or because it’s become a part of their daily ritual! Perhaps you can relate to this? I know I can, I am a recovered self-proclaimed coffee addict and coinsurer who had to overcome my addiction and dependency to caffeine. Now, if you know that caffeine is not supporting your wellbeing, but you struggle to let it go, this is nothing to feel shame about. Awareness is the first step, and if you decide you want to change your relationship to caffeine, this article is to help educate you and shed insight to the physiological processes of caffeine. Caffeine is possibly the most widely accepted drug in the world. It is found in beverages such as coffee, teas, and even plants such as cacao and guarana. While caffeine may seem relatively harmless, it can have a negative impact on their overall wellbeing. Research on this topic can be conflicting. There are clinical studies that have shown ways in which caffeine can a positive impact on certain individuals. For example, one study highlights the suggestion that coffee may help prevent Alzheimer’s and Parkinson’s disease. Other suggested benefits include a lower risk of depression, improved heart health, and boosted energy. While all of this sounds great, it’s important to keep in mind that there is a lot of financial incentive to keep people consuming caffeine! After discovering my own health difficulties associated with my consumption of caffeine, I began studying the science behind this drug and found that there is much contradicting evidence to the research supporting caffeine consumption. I also found that it is significantly more challenging to come across these studies and rarely are they posted in the public media. Let’s explore some of the contradicting research studies of caffeine while we take a little dive into the science of the drug itself! How caffeine works in the body: Caffeine is a drug of the methylxanthine class of drugs and is considered a stimulant. It works by stimulating the central nervous system, heart, muscles and other organs. It affects the centers that control blood pressure and it is also known as a diuretic, which means that it increases the flow of urine. Caffeine is generally absorbed in the body through the digestive system. The short-term effects are usually experienced within 5-30 minutes and can last up to 12 hours depending on the individual. The most commonly known short term side effects of caffeine include increased breathing rate, increased heart rate, increased physical energy, increased mental alertness, increased frequency in urination, and rise in body temperature. Caffeine affects not only the brain and central nervous system but also the following organ systems: Circulatory and Respiratory Organs -increases blood pressure -can lead to irregular heart rhythms -causes the heart to work harder -can be dangerous for those with hypertension or heart issues Reproductive Organs: -caffeine consumption in pregnancy causes an increased heartrate and metabolism in the unborn baby -caffeine crosses through the placenta and can interfere with the unborn baby’s growth and development and can even lead to miscarriage -caffeine can affect fertility and can interrupt one’s ability to conceive -caffeine interferes with hormones including estrogen production necessary for pregnancy to occur Skeletal and Muscular Organs: -caffeine consumption interferes with absorption of calcium, short term this can lead to muscle aches, pains, cramping and twitching -the interference of calcium absorption over time can contribute to bone thinning Digestive System: -caffeine increases the amount of acid in the stomach -liver is responsible for processing and filtering extra caffeine in the body, which overtime can be stressful for the liver -people with ulcers or acid reflux should be extra cautious for caffeine consumption as caffeine will only exacerbate symptoms of stomach issues Symptoms of Caffeine overdose: Signs that you have consumed to much coffee may include: -Dizziness/headache -anxiety -irritability -acid reflux -depression -difficulty concentrating -thought disturbances -insomnia/sleeplessness -shaking or trembling hands -feeling of exhausting once the caffeine has worn off Neuroscience of Caffeine: Let’s get to the brainy stuff. How does caffeine work in the brain? As we discussed in the previous article, caffeine is a drug. This means that caffeine crosses the blood brain barrier, or the BBB and is notorious for its effect on Adenosine. Adenosine found commonly throughout the CNS and is considered both an excitatory and inhibitory neurotransmitter. It is well known for its inhibitory effects in which it promotes sleep, causes drowsiness, and suppresses arousal. What this means is that caffeine works by blocking feelings of tiredness and thus causes you to feel artificially awake. Physiologically adenosine is known to dilate blood vessels in the brain, and this would likely cause the effect of tiredness or fatigue. What we know about caffeine is that it constricts blood vessels, meaning it causes them to become more narrow and restrict blood flow. This phenomenon explains caffeine withdrawal headaches, as the caffeine wears off and the individual does not take a dose, this can cause the blood vessels to dilate allowing more blood flow to the brain and causing a headache to occur. According to the National Institute on Drug Abuse (NIDA), caffeine also works by enhancing dopamine signaling in the brain via the reward pathway system. This draws attention toward the addictive qualities of caffeine. Although caffeine produces withdrawals, the symptoms tend to be less severe than with other drugs. Caffeine produces symptoms of withdrawal; however, it is listed as a drug of dependence rather than a drug of addiction. This classification is made by the NIDA and the reason for this is because it produces a small rise in dopamine in the brain when compared to other more addictive drugs; including nicotine, amphetamines, and cocaine that produce a larger more excessive rush of dopamine. How to tell if my body is addicted to caffeine: The most common tell-tale sign that your body is addicted to caffeine is that you get a headache when you skip your daily dose. The best way to know if your body is addicted to the caffeine is to try a few days completely without it. If you experience bodily effects that typically are not present for you, this is known as a withdrawal. When you stop your caffeine dose, look out for these well-known signs of caffeine withdrawal: - fatigue - drowsiness - depressed mood - decreased alertness - decreased motivation - feeling foggy There are physical effects of caffeine overdose which can include symptoms of nausea, muscle pain, muscle stiffness/soreness, and even vomiting. Caffeine withdrawal symptoms can start anywhere from 11-24 hours after not consuming caffeine and can last anywhere from 2-9 days, so if you want to see if your body is addicted to caffeine, it would be important to give your body at least 7-9 days to see the full effects of your caffeine dependence. Contraindications of caffeine consumption Medically speaking, there are several situations in which certain individuals should refrain from caffeine. It is important to consider, if there are so many situations that caffeine can be harmful, then is this a good indication that as a society we may want to become more conscious of how we consume this substance. Some of these people and conditions are included in this list below: -mental health disorders including Anxiety disorders, Bipolar disorder, and schizophrenia -epilepsy -children -pregnancy and breastfeeding -Diabetes -Irritable Bowel Syndrome (IBS) -Parkinson’s Disease -Heart Conditions -stimulant drugs included Ephedrine -Adenosine -Antibiotics -Hormones including Estrogen -Medications for Depression -Stimulant drugs including Cocaine *Note! This is not medical advice and should not be replaced by the advice of a medical doctor. This list is not comprehensive and is only being shown to list examples of reasons for which people should avoid caffeine for medical reasons. Other concerns of Caffeine: Where does your caffeine come from? It is important to keep in mind the source of your caffeine. Even if you can tolerate the caffeine itself, it is wise to ensure that your caffeine is sourced from a product that is grown and produced responsibly for both you and the environment. Certain coffees have been tested positive for Mycotoxins which is a type of mold that can be dangerous for your health. It is also important to keep in mind the ethics of the company whether they are growing coffee beans or harvesting tea leaves, producing caffeinated beverages or energy bars, to know that the source is operating ethically and responsibly. Gender differences Much of the research that exists today concerning caffeine is not taking into consideration gender differences. A research study performed by the department of Exercise and Nutrition Sciences and the University of New York, Buffalo examined the gender differences in physiological response to caffeine. They found that male subjects had a more positive overall response to caffeine consumption than their female counterparts. Differences were shown primarily in cardiovascular responses and the researchers suggest that steroid hormones play a role in dictating these differences. Takeaway: Caffeine may not be the innocent substance many of us imagine it to be. While there is no use in demonizing it as a substance, it is important to disclose the possible harmful side effects it may have on us and our health. Even for those who do not seem to suffer harmful side effects from coffee, it is not something to be consumed limitlessly. We wish you have this conversation with you to help bring awareness to what we consume, and to better explain why it is important to eliminate caffeine from your diet during your micro dosing protocol. Even if you struggle from caffeine dependence and you wish to change it, be sure to be easy on yourself. Reach out to our team for support, talk to a friend, and most importantly give yourself time. Micro dosing can help to solidify changes you are making to your caffeine consumption so even if you are able to stop for your micro dosing journey you might be surprised that the changes further solidify by the end of your month. In the next article we will discuss the importance of eliminating caffeine for your micro dosing protocol and other ways to successfully reframe your mind around caffeine consumption. Citations: Temple JL, Ziegler AM. Gender Differences in Subjective and Physiological Responses to Caffeine and the Role of Steroid Hormones. J Caffeine Res. 2011 Mar;1(1):41-48. doi: 10.1089/jcr.2011.0005. PMID: 24761262; PMCID: PMC3621315. Levi C. Mycotoxins in coffee. J Assoc Off Anal Chem. 1980 Nov;63(6):1282-5. PMID: 7451391. Addicott MA, Yang LL, Peiffer AM, Burnett LR, Burdette JH, Chen MY, Hayasaka S, Kraft RA, Maldjian JA, Laurienti PJ. The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate? Hum Brain Mapp. 2009 Oct;30(10):3102-14. doi: 10.1002/hbm.20732. PMID: 19219847; PMCID: PMC2748160. Sajadi-Ernazarova KR, Anderson J, Dhakal A, Hamilton RJ. Caffeine Withdrawal. 2022 Sep 18. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 28613541. Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl). 2004 Oct;176(1):1-29. doi: 10.1007/s00213-004-2000-x. Epub 2004 Sep 21. PMID: 15448977. Sebastião AM, Ribeiro JA. Adenosine receptors and the central nervous system. Handb Exp Pharmacol. 2009;(193):471-534. doi: 10.1007/978-3-540-89615-9_16. PMID: 19639292. Alasmari F. Caffeine induces neurobehavioral effects through modulating neurotransmitters. Saudi Pharm J. 2020 Apr;28(4):445-451. doi: 10.1016/j.jsps.2020.02.005. Epub 2020 Feb 17. PMID: 32273803; PMCID: PMC7132598. Hong CT, Chan L, Bai CH. The Effect of Caffeine on the Risk and Progression of Parkinson's Disease: A Meta-Analysis. Nutrients. 2020 Jun 22;12(6):1860. doi: 10.3390/nu12061860. PMID: 32580456; PMCID: PMC7353179. Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA. The Safety of Ingested Caffeine: A Comprehensive Review. Front Psychiatry. 2017 May 26;8:80. doi: 10.3389/fpsyt.2017.00080. PMID: 28603504; PMCID: PMC5445139.
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From Drug to Natural Medicine
We will be highlighting some fewer known facts about the D-word: Drugs. Society seems to be wakening to the reality that this world has become largely consumed by drugs, or rather, consumed by consuming drugs. We are here to help place more awareness to the dangers of more general drug use and to encourage people to take a break from substances to make space for reflection and physical and mental detox. If you are abstaining from alcohol, nicotine or another substance, I invite you to use our micro dosing protocol to help you through the month. I understand it may seem contradictory to use a so-called “drug” in order to help abstain from another “drug”, but there are many misconceptions about drugs including psilocybin and I am here to clear up a few discrepancies for you. Yes! That means we are de-stigmatizing drugs- all of them- and especially the ones that have the potential to have positive impact, such as psilocybin. Remove Good/Bad language from your vocabulary when speaking on “psychoactive drugs” The first important lesson: there is nothing inherently good or bad about a drug, however, using a drug without conscious awareness or consideration for how it is impacting the neurophysiology of your brain, and subsequently the other organs and systems of your body, and life can be incredibly harmful. Even a drug as seemingly innocent as caffeine can have fatal side effects for people living with certain medical conditions. And the undeniable truth is that all psychoactive drugs will impact us in some way or another- it’s time we start normalizing this truth and speak openly about the consequences! What classifies something as a psychoactive drug? What is most important is that all drugs have one thing in common- they pass through the BBB in the brain. The BBB (aka Blood Brain Barrier) is a structural and functional barrier designed to protect the brain from destructive molecules such as viruses, fungi, parasites or bacteria that may be floating around the body. Drugs can cross over this barrier and thus impact the neurobiology of the brain. As the entire body is incredibly interconnected, this means that once the drug influences the brain it will subsequently begin effecting the other organs and systems of the body, or the other way around. The Brain is your body’s best friend and Vice-Versa It is so important to remember, the brain is never isolated!!! It is a vast, intelligent organism that communicates constantly between the other organs in the body. Just like going for a run and having physical exercise impacts the physiology of your actual brain cells, putting a drug into your body and altering your brain chemistry will always impact your body. This would explain why symptoms of body aches and muscle cramping exist in some people with alcohol addiction. The medical term for this is alcohol neuropathy which is when the nerves throughout the body become damaged from excessive alcohol intake. So, when you ingest a drug, try to not only think about its impact on the brain but also your heart, lungs, nervous system, kidneys, liver, etc etc. It’s a lot to think about and therefore it’s so important that we have a general understanding of the psychoactive substances most of us are ingesting on a daily basis. Duped by Dopamine There is one commonality between all addictive drugs which is that they all play a role on the dopamine reward system pathway. The exception that psilocybin has when compared to most other classified psychoactive drugs is that it does not play the same role in this system, thus this eliminates the element of having an addictive quality. This principle applies to many other psychedelic substances which is becoming more and more recognized through psychedelic research. This goes to say, you don’t have to worry about becoming addicted to psilocybin whether you are taking a macro or micro dose. Not all psychoactive drugs are created Equal! If I would begin listing the extensive list of psychoactive drugs on the market today you would surely lose my attention, if you haven’t already, so I’ll spare you the misery. The list includes substances that are grown as wild and natural plants, lab created substances and street drugs- which are often the most addictive and fatal ones available. Each psychoactive drug is so unique in its biochemical makeup that it is foolish to label them all into one category. In fact, this is somewhat recognized on an institutional level which is why they have been categorized into “schedules”. There are currently 5 distinct schedules and they are meant to be ranked according to levels of abuse potential, and whether there is a currently approved medical “need” or application for the substance. Unfortunately this list is biased by politics and there is much controversy as to the accuracy and relevance of the schedules as they exist today. When ingesting a substance, keep in mind the variables that contribute to the actual manufacturing of this drug. Is it nature grown, or lab grown? Has the substance been tested for pollutants and toxins? Is the drug pure or mixed with other potentially harmful molecules? These days the quality of natural/organic wine versus conventional wine can even make a remarkable difference when considering its overall impact on the body. Are you still with me? This information is dense but it is important to understand that there is a long history of the idea of a psychoactive “drug”, and the word itself is heavily weighted. Unlearning everything you know about drugs may take some time, but we’re here to help. If you have questions, please don’t hesitate to reach out to our team and we will guide you toward resources to help you make more informed decisions in the future. Additionally, I hope this article will aim to destigmatize the word “drug” and provide a deeper understanding to what classifies a substance as a drug and at which point you can detect if you have an unhealthy relationship with a substance. Is psilocybin technically a drug? Psilocybin is a member of the psychedelic class of drugs. The word drug itself sounds a bit harsh and loaded. You may find it intimidating, off-putting and have several assumptions about this word with associations such as cocaine, heroin, and other “street drugs”. Allow me to fill you in on a little secret…. Many things we consume daily are considered drugs, albeit more socially accepted drugs, they are still drugs. This includes alcohol, nicotine, caffeine and yes, even sugar. So … by now you must be wondering.. How about psilocybin? Is it really a drug, and can it help me or does it have potential to harm me? Psilocybin is technically considering a drug under the class of hallucinogenic psychedelic drugs. It is a naturally occurring substance derived from specific types of mushrooms native to the Americas including Mexico, The United States, and South America. Psilocybin can be ingested either through the mushroom itself or it can be extracted and isolated through chemical processes. Psilocybin is a non-addictive substance meaning that it is not influencing the dopamine-driven reward system pathway. There is currently no research to support that Psilocybin has any negative effect on the organs of the body including the brain however, there are certain contraindications in which individuals should receive medical clearing before ingesting psilocybin. Those with heart disease Pregnant individuals Suffering with a severe drug addiction including symptoms of withdrawals Alcohol abuse In the middle of a life crisis Family history of schizophrenia or bipolar disorder Taking drugs with MAO inhibitors including Marplan, Emsam, Parnate If you have any doubts whether you fall into one of these categories, please consult your physician. While psilocybin is a safe drug, everyone responds differently and therefor consideration and respect is a must. Please reach out to our team with any questions! If Psilocybin does not work primarily with dopamine, then how does it work? A brief explanation of the chemical mechanism of this drug is that it begins as the psilocybin molecule and later converts to the active ingredient psilocin. Psilocin activates many neurotransmitter receptors although it is best known for its affinity for serotonin receptors (aka 5-HT2A receptors). Serotonin is known for its role in regulating mood, cognition, reward and memory. It is interesting to note that most of our estimated 40 million brain cells are influenced by serotonin. Additionally, it’s important to note that although we have serotonin receptors in the brain, most of its supply is found in the digestive tract! (remember when I told you how interconnected our brain is to the rest of our body?!) What is powerful about psilocybin is that it has been found to have a positive impact in regulating the release and uptake of serotonin and does not leave the body in a state of withdrawal or dependence. The final important note to make about micro dosing psilocybin is that while a microdose does impart beyond the BBB, it is a subperceptual dose meaning that it is not high enough of a dose to alter the state of consciousness of the mind. When you think of drugs it is important to consider the dose and the body’s tolerance. Taking a subperceptual dose has very little potential to do any damage or disruption of any kind, and yet still has potential for benefiting the health and overall wellness of the mind and body! A truly miraculous drug if you ask me, in the right set and setting, for the right individual and in it’s right timing, this is a drug to rave about. In the Psychedelic and Scientific Community therefor Psilocybin is often referred to as Natural Medicine or plant medicine. Citations: Lee HM, Roth BL. Hallucinogen actions on human brain revealed. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1820-1. doi: 10.1073/pnas.1121358109. Epub 2012 Jan 30. PMID: 22308478; PMCID: PMC3277578. Dinis-Oliveira RJ. Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance. Drug Metab Rev. 2017 Feb;49(1):84-91. doi: 10.1080/03602532.2016.1278228. Epub 2017 Jan 31. PMID: 28074670. Nichols DE. Psychedelics. Pharmacol Rev. 2016 Apr;68(2):264-355. doi: 10.1124/pr.115.011478. Erratum in: Pharmacol Rev. 2016 Apr;68(2):356. PMID: 26841800; PMCID: PMC4813425. Johnson MW, Garcia-Romeu A, Griffiths RR. Long-term follow-up of psilocybin-facilitated smoking cessation. Am J Drug Alcohol Abuse. 2017 Jan;43(1):55-60. doi: 10.3109/00952990.2016.1170135. Epub 2016 Jul 21. Erratum in: Am J Drug Alcohol Abuse. 2017 Jan;43(1):127. PMID: 27441452; PMCID: PMC5641975. Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PC, Strassman RJ. Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol. 2015 Mar;29(3):289-99. doi: 10.1177/0269881114565144. Epub 2015 Jan 13. PMID: 25586396. Dos Santos RG, Bouso JC, Rocha JM, Rossi GN, Hallak JE. The Use of Classic Hallucinogens/Psychedelics in a Therapeutic Context: Healthcare Policy Opportunities and Challenges. Risk Manag Healthc Policy. 2021 Mar 5;14:901-910. doi: 10.2147/RMHP.S300656. PMID: 33707976; PMCID: PMC7943545. Daneman R, Prat A. The blood-brain barrier. Cold Spring Harb Perspect Biol. 2015 Jan 5;7(1):a020412. doi: 10.1101/cshperspect.a020412. PMID: 25561720; PMCID: PMC4292164. Avena NM, Rada P, Hoebel BG. Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev. 2008;32(1):20-39. doi: 10.1016/j.neubiorev.2007.04.019. Epub 2007 May 18. PMID: 17617461; PMCID: PMC2235907.
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The Default Mode Network and how it’s impacted by Psychedelics
What is the Default Mode Network (DMN)? The default mode network is an interactive group of brain regions that is found to be most active when a person is in a resting state. This brain activity is associated with focused thinking on self and others, rumination on the past, and thoughts of the future. The DMN is the “default” setting of the brain that help us function in the world. While there is nothing inherently wrong with this setting of the brain, fMRI studies show that hyperactivity of this network of the brain is linked to mental health conditions including anxiety, depression, Alzheimer’s Disease, OCD, Schizophrenia and even chronic pain. Essentially, there is a healthy level of remembering past events, thinking toward the future, and recognizing the actions of others and how they impact us, but hyperactivity of this network causes obsessive thinking, rumination over negative experiences and thoughts, and even inaccurate thoughts about ourselves, others, and our experiences in the world. How does Psilocybin impact the DMN? Psilocybin is known to profoundly impact activity in the DMN by weakening neural connections within the network. “Ego Death” is a common phrase used when people describe their psychedelic experiences. This term refers to the dissolution of the Ego, meaning thoughts of the individual focus less on the self and borders between the self and the outside world seem to dissolve. The term of “Ego Death” is what is commonly referred to when people Identify their experience as bringing a sense of unity or oneness to their awareness. Although Psilocybin initially decreases activity of the DMN, research suggests that after some time the DMN is reestablished. You can imagine it’s as though you are hitting reset on the DMN, ultimately impacting your default thoughts, patterns and behaviors. The dissolutions of the DMN also relates to the more chaotic or disordered state of the brain that is shown in individuals who have ingested psychedelics. While the DMN is an essential part of being able to function in our day-to-day life, research suggests that it is often hyperactive causing unnecessary stress and dissatisfaction. Meditation is a commonly known mediation for deactivating the DMN, however recent psychedelic research studies indicate that psychedelics may have a profound impact on the DMN, especially with the ability to “reset” the DMN and allow the mind a more balanced relationship within this network. Research: https://pubmed.ncbi.nlm.nih.gov/26010878/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553600/ Carhart-Harris RL, Leech R, Hellyer PJ, et al. The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Frontiers in Human Neuroscience. 2014;8. doi:10.3389/fnhum.2014.00020 Andrews-Hanna JR. The brain's default network and its adaptive role in internal mentation. Neuroscientist. 2012 Jun;18(3):251-70. doi: 10.1177/1073858411403316. Epub 2011 Jun 15. PMID: 21677128; PMCID: PMC3553600.
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How Microdosing May Rewire Your Brain
A Disorganized Brain Our rational mind might think that we should have a perfectly organized and controlled brain, but often that is exactly what leads us to our own unhappiness. For example, someone with depressive symptoms might ruminate over the same (organized) depressive thoughts day in and day out exacerbating their depressive symptoms. Science has shown that psychedelics create a more disorganized brain environment, allowing for new perspectives and ideas to shine through! The moral of the story is this: leaving the bed undone and letting go of control might be the answer when it comes to our mental health, and psychedelics help us do this. It’s not that we stop striving for better but letting go of control over our rational mind might help us to have a new perspective on things out of our control, and open space to act on the things we can control. New Relationships between lobes: Another finding that has been shown on brain scans of those under the effects of psychedelics is that this new disorganized brain environment allows some regions that we normally keep in the background (visual/hearing) to come to center stage, and new relationships between the lobes begin to form. This helps explain the visual hallucinations that might be experienced by people who take larger doses of Psilocybin or LSD. In other words, the information passing through the region of the brain responsible for vision or for hearing will be emphasized, while the more executive functions of the brain are subdued. If you consider what might happen on a micro scale (think micro-dose), these regions are now getting more of a voice than our conscious brain allows, and often presents bright, new, exciting perspectives that simply have no place to shine when we are in our normal, controlled state of consciousness. Serotonin Receptor Activation Serotonin is known as the “happy” neurotransmitter. Psilocybin activates serotonin receptors which can improve mood, memory, sexual appetite and sleep. Activating these receptors with psilocybin can reinforce these neural pathways and overtime can be more easily accessible. Think of a neural pathway as the path you walk while you are hiking, every hike that has been taken before you has only reinforced this path to create a clear and defined pathway for you to walk. The brain is wired so that it defaults to what is known, or what is familiar, so the more frequently and consistently a path is taken, the more natural it becomes. Now ask yourself this, imagine if every day you took a walk down the path of being present, accepting what is and acting on the things that matter to you most, the more times you walk down this path, and the more frequently you take this path, the clearer, more focused and strengthened it becomes. Growth of New Neurons To continue with the hiking analogy, now imagine your neurons are trees, because well, they do look like trees! The base of the neuron, called a dendrite, looks like the branches coming out of a tree. Research has shown that Psychedelics such as Psilocybin stimulate the growth of brain cells, or neurons. Not only do these magical fungi stimulate neuronal growth, but they also increase the rate at which they are fired, meaning these paths to happiness and improved mood are happening at consistent and rapid rates! Now that you have a better idea of some of the ways Micro dosing can help to rewire your brain you can apply this knowledge while preparing for your next micro dosing journey. It helps to know that whatever intentions you set before your journey are already creating the pathways that will be reinforced as you allow the fungi to work their magic. Keep in mind, it Is a collaborative effort and these drugs while powerful and magical do not make the changes for you! Citations: Daws, R.E., Timmermann, C., Giribaldi, B. et al. Increased global integration in the brain after psilocybin therapy for depression. Nat Med 28, 844–851 (2022). https://doi.org/10.1038/s41591-022-01744-z Nutt D, Carhart-Harris R. The Current Status of Psychedelics in Psychiatry. JAMA Psychiatry. 2021;78(2):121–122. doi:10.1001/jamapsychiatry.2020.2171 Activation of Serotonin 2A Receptors Underlies the Psilocybin-Induced Effects on α Oscillations, N170 Visual-Evoked Potentials, and Visual Hallucinations Michael Kometer, André Schmidt, Lutz Jäncke, Franz X. Vollenweider
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